Post-induction hypotension
Conditions
Interventions
Experimental Group:The fospropofol disodium group received fospropofol disodium injection (0.2 ml/kg) and 20% long chain fat emulsion placebo (0.4 ml/kg)
Control group:The control group received propofol medium/long chain fat emulsion (0.4 ml/kg) and normal saline placebo (0.2 ml/kg).
Sponsors
Qilu Hospital of Shandong University (Qingdao)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18 to 65 years, any gender; 2. American Society of Anesthesiologists (ASA) physical status classification I–III; 3.Scheduled to undergo elective laparoscopic surgery under general anesthesia (e.g., cholecystectomy, appendectomy, gynecologic laparoscopic surgery), with an expected surgical duration <= 2 hours; 4.Body mass index (BMI) 18.5–30.0 kg/m^2; 5.Voluntarily participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1: Known allergy to propofol, phosphopofol, soy, or eggs; 2: Severe cardiovascular diseases: Uncontrolled hypertension Unstable angina New York Heart Association (NYHA) functional class III–IV Severe arrhythmias; 3: Severe hepatic or renal dysfunction: Child-Pugh class B or C eGFR < 60 mL/min/1.73m^2; 4: Central nervous system disorders, history of psychiatric illness, or long-term use of sedatives, hypnotics, or antiepileptic drugs; 5: Predicted difficult airway; 6: History of chronic alcoholism or drug abuse; 7: Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-induction hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum BIS value;Time for BIS to decline from baseline to 50;Mean slope of BIS decline from baseline to the lowest value.;Proportion of patients with burst suppression (BIS 0) during induction.;Incidence of injection pain;Incidence of bradycardia (HR < 45 beats/min);I ncidence of postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactJianjun Li
Qilu Hospital of Shandong University (Qingdao)
Outcome results
None listed