Localized advanced prostate cancer
Conditions
Interventions
Treatment group:Abiraterone treatment + Radical prostatectomy
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. The prostate biopsy diagnosis was prostatic acinar adenocarcinoma, with clinical stage T3b - T4NxM0 or TxN1M0. 2. Age is less than or equal to 85 years old. 3. Expected lifespan is over 10 years. The patient intends to undergo radical prostate cancer resection surgery and there are no obvious surgical contraindications. 4. ECOG score = 70g/L, white blood cell >= 3.5×10^9/L, and neutrophil >= 1.5×10^9/L; b) Creatinine <= 1.5× upper limit of normal (UNL); c) Alanine aminotransferase (ALT) <= 1.5× UNL; aspartate aminotransferase (AST) <= 1.5× UNL; alkaline phosphatase (ALP) <= 1.5× UNL; d) Total bilirubin (TBIL) <=2.5× UNL.
Exclusion criteria
Exclusion criteria: 1. There are serious heart and lung-related diseases, and one is unable to withstand surgery or chemotherapy. 2. Metastasis of bone or internal organs (M1); 3. Metastasis of bone or internal organs (M1) combined with the following diseases: autoimmune diseases, infectious diseases (HIV, HBV, HCV), severe cardiovascular and cerebrovascular diseases (history of previous myocardial infarction, cerebral infarction), thrombosis-related diseases, interstitial pneumonia; 4. Suspected or with a confirmed history of alcohol or drug abuse; 5. Those who are allergic to this experimental drug and its components.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No biochemical resuscitation survival time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiographic Progression-Free Survival (rPFS);Incidence of adverse reactions;Treat the root cause of the disease and the rates of CR and MRD; | — |
Countries
China
Contacts
Public ContactHou Huimin
Beijing Hospital
Outcome results
None listed