Stroke
Conditions
Interventions
left DLPFC group:The TMS intervention employed an intermittent theta-burst stimulation (iTBS) protocol. The stimulation target was the left dorsolateral prefrontal cortex (DLPFC), with its scalp proje
each train consisted of 10 bursts of three pulses at 50 Hz (repeated every 200 ms for 2 s, resulting in 10 bursts and 30 pulses per train). The inter-train interval was 8 s, yielding a total of 600 pu
right PPC group:The stimulation target was the right posterior parietal cortex (PPC) of the affected hemisphere, localized at the P4 electrode position of the 10–20 EEG system. High-frequency repetiti
sham stimulation group:The sham group used the same device, stimulation site, treatment frequency, and session duration as the active iTBS group, but was equipped with a sham coil. The sham coi
Sponsors
Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the unilateral spatial neglect (USN) group 1. First-ever stroke, confirmed by head CT or MRI as right-hemisphere cerebral hemorrhage or cerebral infarction, with a post-stroke duration of 2 weeks to 1 year; 2. Right-handed; 3. Aged 18–85 years; 4. Signed informed consent obtained from the patient or their family member; 5. Ability to cooperate with pre- and post-treatment assessments; 6. Presence of unilateral spatial neglect confirmed by the Apple Cancellation Task (ACT) of the Birmingham Cognitive Screen (BCoS), supplemented by clinical observation when necessary. Inclusion criteria for the non-USN group Absence of unilateral spatial neglect as determined by the Apple Cancellation Task (ACT) of the Birmingham Cognitive Screen (BCoS) and the Behavioural Inattention Test–Conventional (BIT-C); the remaining criteria are identical to items 1–5 of the USN group. Inclusion criteria for the healthy control (HC) group 1. No personal or family history of neuropsychiatric disorders or substance abuse; 2. No history of alcohol abuse, sleep deprivation, or any condition affecting psychological and cognitive health; 3. Normal or corrected-to-normal vision; 4. Right-handed; no upper limb dysfunction; no significant cognitive impairment and capable of independent living; 5. Aged 18–85 years; 6. Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Patients with Right-Hemisphere Stroke 1. Subarachnoid hemorrhage, transient ischemic attack (TIA), progressive stroke, or reversible ischemic neurological deficit (RIND); 2. Severe comorbidities involving the heart, lungs, liver, kidneys, or other major organs; 3. Concurrent psychiatric or neurological disorders, such as Parkinson’s disease, dementia, brain tumor, or schizophrenia; 4. History of seizures or epilepsy; 5. Presence of metallic implants in the body (e.g., cochlear implant, cardiac pacemaker, intracranial arterial stent, intracranial vascular coil, ventriculoperitoneal shunt); 6. Skull defect or cranial bone absence; 7. Severe uncorrectable visual impairment or visual field defects; 8. Pregnancy. Exclusion Criteria for Healthy Controls 1. Pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral Inattention Test-Conventional (BIT-C); | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Catherine Bergego Scale (CBS);Fugl-Meyer Assessment (FMA);Berg Balance Scale (BBS);Modified Barthel Index (MBI);functional near-infrared spectroscopy (fNIRS); | — |
Countries
China
Contacts
Public ContactXin Li
Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed