Perinatal anxiety and depression
Conditions
Interventions
Dexmedetomidine group:Intranasal dexmedetomidine at a dose of 1µg/kg
Placebo group:Administer the same amount of normal saline intranasally
Sponsors
Nanjing Medical University Affiliated Maternity Hospital (Nanjing Maternal and Child Health Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. women aged 18-50 years old;2. with ASA classification of I or II; 3.who are pregnant and have experienced miscarriage (including missed abortion, spontaneous abortion or empty pregnancy); 4.with a score of >=5 on the Generalized Anxiety Disorder-7 (GAD-7) scale (indicating mild or above levels of anxiety);5.and who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Body weight 30 kg/m^2; 2. Lactating patients; 3. Those with a history of sleep apnea; 4. Those currently using opioid or non-opioid analgesics for pain control; 5. Those currently taking other drugs that can affect sedation and analgesia responses, such as central a-adrenergic drugs (clonidine or dexmedetomidine, etc.), antiepileptic drugs, neuroleptics, antidepressants, antipsychotic drugs, etc.; 6. Those who have used corticosteroids within 3 months; 7. Preoperative electrocardiogram abnormalities (prolonged QTc, frequent ventricular premature beats, etc.) and liver and kidney function impairment; 8. Other postoperative exclusion criteria include: anesthetic adverse events such as allergy, bronchospasm, hemodynamic instability during surgery, as well as surgery-related adverse events such as uterine perforation and intestinal injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety score 7 days after the operation, the rate of decline in anxiety score and the rate of anxiety relief;Anxiety score 42 days after the operation, the rate of decline in anxiety score and the rate of anxiety relief;Anxiety score 180 days after the operation, the rate of decline in anxiety score and the rate of anxiety relief;Anxiety score 360 days after the operation, the rate of decline in anxiety score and the rate of anxiety relief; | — |
Secondary
| Measure | Time frame |
|---|---|
| The dosage of propofol used during the operation, the incidence of adverse events such as hypoxemia, hypotension, bradycardia, and postoperative nausea and vomiting;The quality of recovery 24 hours after the operation, postoperative pain score, postoperative sleep quality;Short-term and long-term postoperative (on the 7th day, 42nd day and half a year/year after the operation) depression and grief scores and their remission status;Functional magnetic resonance imaging (MRI) examinations were conducted before and after the operation; | — |
Countries
China
Contacts
Public ContactFeng Shanwu
Nanjing Medical University Affiliated Obstetrics and Gynecology Hospital (Nanjing Maternal and Child Health Hospital)
Outcome results
None listed