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Study on Efficacy and Brain Network Mechanism of Gutongling Tincture Combined with tDCS in the Treatment of Knee Osteoarthritis

Study on Efficacy and Brain Network Mechanism of Gutongling Tincture Combined with tDCS in the Treatment of Knee Osteoarthritis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600125536
Enrollment
Unknown
Registered
2026-05-28
Start date
2026-06-19
Completion date
Unknown
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Gutongling Tincture Group (Group A):Soak dressing with 10ml Gutongling Tincture, apply to affected area for 30 minutes, once daily.
tDCS Group (Group B):tDCS treatment: IS300A transcranial direct current stimulator manufactured by Sichuan Intelligent Electronics Industrial Co., Ltd. was adopted. Treatment parameters: direct curren
Combined Treatment Group (Group C):External application of Gutongling Tincture (same as Group A) combined with simultaneous tDCS treatment (same as Group B)

Sponsors

Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Knee joint pain lasting more than one month; 2. Age no less than 40 years old; 3. Morning stiffness duration =25%) in any position; Patients satisfying criteria 1+2+3+4+5 or 1+6 are eligible for enrollment.

Exclusion criteria

Exclusion criteria: 1. Presence of metabolic arthritis; 2. Infectious diseases of the knee joint; 3. Previous knee surgery history, including knee arthroplasty, tibial osteotomy, etc; 4. History of neurological diseases such as brain tumor, epilepsy and stroke.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale(VAS) score;Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC;

Secondary

MeasureTime frame
Lequesne Index ;Functional near infrared spectroscopy(fNIRS);

Countries

China

Contacts

Public ContactYinxu Wang

Affiliated Hospital of North Sichuan Medical College

34089681@qq.com+86 134 3878 1951

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jul 23, 2026