Colorectal cancer
Conditions
Interventions
Methylene Blue Combined with Ropivacaine Group MR Group:The MR group received ultrasound-guided bilateral TAPB at the mid-axillary line level with a 20-ml solution of 0.375% ropivacaine plus 0.05% met
Ropivacaine Group R Group:Inject 20 ml of 0.375% ropivacaine hydrochloride injection on each side (7.5 ml of 1% ropivacaine hydrochloride + 12.5 ml of 0.9% sodium chloride injection). The total bilate
Sponsors
Shanxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Classified as ASA grade II~III by the American Society of Anesthesiologists (ASA); 2. Age between 18 and 75 years; 3. Body mass index (BMI) between 18 and 30 kg/m^2; 4. Each patient was preoperatively diagnosed with primary colorectal cancer, with no distant metastasis detected; 5. All surgeries were laparoscopic radical resections of rectal cancer, and all were sphincter-preserving procedures; 6. Surgery duration > 2 hours.
Exclusion criteria
Exclusion criteria: 1. BMI 30; ASA classification: Grade IV or above; 2. Patients with contraindications to nerve block, including coagulation abnormalities, severe infection at the puncture site or systemic infection, etc.; 3. Known allergy to related drugs; 4. Patients with certain neuromuscular system diseases; 5. Patients with higher intraocular pressure; 6. Long-term use of analgesics or antipsychotic drugs; 7. Patients who refuse to participate in the study; 8. Postoperative transfer to ICU, postoperative severe infection, or recurrence requiring secondary surgery; 9. Conversion from laparoscopic to open surgery; 10. Patients with severe complications or loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| opioid consumption;Inflammatory factor level;Immune cell subset count;First anal time;First time out of bed and active (hours); | — |
Countries
China
Contacts
Public ContactZhang Weiwei, Chen Fujian
Shanxi Provincial People's Hospita
Outcome results
None listed