Early postoperative neuro-cognitive disorders (PND)
Conditions
Interventions
Light Anesthesia Group:ciprofol and remifentanil infused at a fixed ratio to maintain a relatively light anesthesia
Deep Anesthesia Group:ciprofol and remifentanil infused at a fixed ratio to maintain a relatively deep anesthesia
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >=65 years; 2.Planned to undergo non-cardiac surgery under general anesthesia with an expected surgery duration >=1 hour; 3.Requiring patient-controlled intravenous analgesia (PCIA) postoperatively; 4.Signed informed consent form;
Exclusion criteria
Exclusion criteria: 1. Unable to communicate before the operation due to visual, auditory, language impairments or severe dementia; 2. Preoperative conditions such as schizophrenia, epilepsy, Parkinson's disease, and myasthenia gravis; 3. Craniocerebral injury or neurosurgery; 4. Severe abnormal liver function (Child-Pugh grade C); 5. Severe renal dysfunction (eGFR = grade IV; 7. It is expected that the patient will be admitted to the ICU with a tube after the operation; 8. Participate in other clinical studies; 9. Situations where other researchers or attending physicians consider it inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative day 3/discharge dNCR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 4 days/discharge;Incidence of postoperative day 30 pNCD; | — |
Countries
China
Contacts
Public ContactSong Linlin
Peking University First Hospital
Outcome results
None listed