Postherpetic Neuralgia
Conditions
Interventions
Experimental Group:Oxycodone/Acetaminophen + pregabalin
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Definite diagnosis of herpes zoster-associated neuralgia confirmed by relevant laboratory tests and examinations. 2.Presence of breakthrough pain (transient pain exacerbation), defined as spontaneous episodes or pain triggered by predictable/unpredictable factors superimposed on persistent background pain, with >3 episodes per day in the past week and Numeric Rating Scale (NRS) score >=4. 3.Age >18 years. 4.Willingness to provide informed consent and ability to complete follow-up.
Exclusion criteria
Exclusion criteria: 1.Bleeding disorders, bronchial asthma, or severe hepatic/renal insufficiency. 2.Known hypersensitivity to opioids, acetaminophen, or pregabalin. 3.Concurrent severe painful conditions (e.g., cancer pain). 4.Pregnancy, lactation, or planned pregnancy. 5.Participation in other investigational drug trials within the preceding 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Relief Rate;Assessment of breakthrough pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality Assessment;Quality of Life Score (QoL Score);Levels of Pain Mediators and Stress Hormones;Time to First Stable Pain Control;Hospital Anxiety and Depression Scale (HADS) Score;Incidence of Adverse Reactions;Daily Dose; | — |
Countries
China
Contacts
Public ContactSun Tao
Shandong Provincial Hospital
Outcome results
None listed