Pituitary adenoma
Conditions
Interventions
Observation group(The surgical approach of transsphenoidal pituitary tumor resection via the sphenoid sinus ostium using the technique of "preserving the sphenoid sinus mucosa and avoiding routine nas
Control group(Underwent conventional transnasal-septal or transnasal-transsphenoidal approach for pituitary tumor surgery.):None
Sponsors
General Hospital of Northern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Pituitary adenoma confirmed by preoperative MRI and postoperative pathology, suitable for transsphenoidal surgery; 3. First operation, no history of previous transnasal skull base or sphenoid sinus surgery; 4. Preoperative nasal endoscopy and paranasal sinus CT showing well-developed sphenoid sinus, identifiable sphenoid ostium, and no severe sinusitis; 5. Able to cooperate with olfactory testing and follow-up assessments, and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients requiring significantly extended endonasal approach for resection of extensive parasellar, suprasellar or frontal basal tumors with anticipated high-flow cerebrospinal fluid (CSF) leakage; 2. Severe anatomical abnormalities of the nasal cavity (severe nasal septum deviation, multiple nasal polyps, fungal sinusitis, etc.); 3. Preoperative moderate to severe olfactory dysfunction or severe nasal diseases; 4. Complicated with severe systemic diseases intolerant to surgery or long-term follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Olfactory Function;Nasal-Related Quality of Life;Operative Time;Intraoperative Blood Loss;Length of Hosptial Stay;Preoperative Olfactory Function;One-month Postoperative Olfactory Function;Three-month Postoperative Olfactory Function;One-month Postoperative Nasal Quality of Life;Three-month Postoperative Nasal Quality of Life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tumor Resection Rate;Adrenocorticotropic Hormone;Follicle-Stimulating Hormone;Luteinizing Hormone;Prolactin;Thyroid-Stimulating Hormone;Cerebrospinal Fluid Leak;Major Nasal Hemorrhage;Nasal Septum Perforation;Nasal Adhesion;Chornic Sinusitis;Sphenod Sinus Mucosal Cyst;Epistaxis; | — |
Countries
China
Contacts
Public ContactHong Qu
General Hospital of Northern Theater Command
Outcome results
None listed