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Dynamic prediction model for timing of invasive mechanical ventilation initiation in sepsis based on integration of plasma proteomics and clinical indicators

Dynamic prediction model for timing of invasive mechanical ventilation initiation in sepsis based on integration of plasma proteomics and clinical indicators

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600125502
Enrollment
Unknown
Registered
2026-05-27
Start date
2026-05-27
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis patients (including comorbidities) receiving mechanical ventilation

Interventions

IMV:None
NIV:None

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Sepsis patients meeting the Sepsis-3 diagnostic criteria; 2. Meeting the Sepsis-3 diagnostic criteria for sepsis; 3. Presenting with acute respiratory insufficiency requiring non-invasive ventilation (NIV) as initial respiratory support; 4. Informed consent signed within 24 hours of enrollment (by the patient or their authorized representative).

Exclusion criteria

Exclusion criteria: 1. Receiving invasive mechanical ventilation at the time of admission; 2. Combined with irreversible underlying diseases (advanced malignancy, end-stage liver/renal failure); 3. Expected ICU survival time < 24 hours; 4. Refusal to participate or inability to obtain samples on schedule.

Design outcomes

Primary

MeasureTime frame
PaO2/FiO2;Blood lactate;Respiratory rate;—

Countries

China

Contacts

Public ContactMaomao Cao

Peking Union Medical College Hospital

maomaocao1101@163.com+86 10 69156107

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026