None
Conditions
Interventions
Amnesia-analgesia slow induction intubation (study group):Atomization inhalation of 1 % tetracaine was used for surface anesthesia, Slow induction of alfentani combined withdexmedetomidine
Sponsors
Hefei First People's Hospital
Eligibility
Sex/Gender
All
Age
75 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Elderly patients scheduled for lower limb orthopedic surgery, including tibia and fibula fractures and hip fractures (femoral neck fractures, intertrochanteric femoral fractures); (2) Estimated surgery time: 1–2 hours; (3) American Society of Anesthesiologists (ASA) Physical Status III–IV; (4) Age 75–99 years, any gender; (5)Sign a written informed consent form;
Exclusion criteria
Exclusion criteria: (1)Patient refusal; (2) Body mass index (BMI) > 30 kg/m^2 or 180 mmHg); (4) Allergy to relevant anesthetic agents; (5) Presence of psychiatric or neurological disorders, or language barriers, preventing communication and cooperation with treatment; (6) Severe hepatic or renal insufficiency; (7) Long-term use of sedative or analgesic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events (intraoperative awareness postoperative cognitive dysfunction postoperative delirium);Status of recovery;Bispectral index (Bis);Pulse oxygen saturation;Status of recovery;Status of recovery;The dosage of etomidate, cis-atracurium and alfentanil during operation;Cough reaction during extubation and sore throat after extubation; | — |
Countries
China
Contacts
Public ContactYang Heng
Hefei First People's Hospital
Outcome results
None listed