Postherpetic Neuralgia Combined with Emotional Disorders
Conditions
Interventions
Control group:sham TMS treatment
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Disease Diagnosis Criteria: (1) Postherpetic Neuralgia: According to the ICD-11 standards, diagnosis requires meeting the following conditions: a. A clear history of shingles; b. Pain with neuropathic characteristics, such as burning, tingling, etc.; c. Pain occurs in the area where the shingles rash previously appeared, usually confined to one side of the body; d. Pain persists for more than 3 months after the rash has healed, and other types of neuropathic pain are excluded. (2)Anxiety and/or Depressive Disorders: Must meet the following criteria: a. Depression: Major depressive disorder (MDD) according to DSM-5 or ICD-11 standards, with a PHQ-9 score between 5 and 14, indicating mild to moderate depression; b. Anxiety Disorder: Generalized anxiety disorder (GAD) according to DSM-5 or ICD-11 standards, with a GAD-7 score between 5 and 14, indicating mild to moderate anxiety. 2. Related Medical History and Disease Course Requirements: (1) Based on the above disease diagnostic criteria, patients included in the study must have a history of postherpetic neuralgia and comorbid anxiety/depression symptoms for at least 6 months; (2)Patients who have received standard antiviral therapy, pharmacological treatment, nerve blocks, or radiofrequency treatment, but report limited or no efficacy, with a VAS score above 3. 3. Other Relevant Criteria: (1) Age: Adults aged 18 to 65 years. (2) Gender: No restriction. (3) Education Level: At least middle school education. (4) Informed Consent: Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Diseases or Treatments Contrary to Inclusion Criteria: (1) Currently suffering from other acute or severe diseases (such as malignancies, acute cardiovascular or cerebrovascular diseases, severe diabetes, etc.) that may affect the study results. (2) Patients undergoing treatment with neural stimulation devices (such as deep brain stimulation, spinal cord stimulation) or pharmacological treatment (such as long-term steroid therapy) that cannot be discontinued. 2. Complications and Other Medical History: (1) Mental Disorders: A history of severe mental illnesses such as schizophrenia, bipolar disorder, epilepsy, etc. (2) Severe cardiovascular or cerebrovascular diseases, liver or kidney insufficiency, immune system disorders, etc., that may impact treatment safety. 3. Pregnant or Breastfeeding Women: Pregnant women, breastfeeding women, or women planning to become pregnant. 4. Factors That Make TMS/fMRI Inappropriate: (1) Presence of metallic implants (such as pacemakers, neurostimulators, etc.) or other contraindications for TMS. (2) Presence of metallic implants (such as pacemakers, neurostimulators, etc.) or other contraindications for fMRI. 5. Other Exclusion Criteria: (1) Currently experiencing an acute pain episode with a pain severity exceeding a VAS score of 8. (2) Patients unable to comply with the study’s treatment or follow-up plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief; | — |
Secondary
| Measure | Time frame |
|---|---|
| Persistence of pain relief;Improvement in mood;Improvement in quality of life;Changes in brain functional connectivity networks; | — |
Countries
China
Contacts
Public ContactLi Juchen
Zhongshan Hospital, Fudan University
Outcome results
None listed