None
Conditions
Interventions
Remimazolam group (experimental group):Anesthesia induction:Remimazolam group (R group): Alfentanil 5 µg/kg + Remimazolam 0.2 mg/kg (slow intravenous injection over 30 seconds).
Propofol group (control group):Propofol group (P group): Alfentanil 5 µg/kg + Propofol 1.5~2 mg/kg (slow intravenous injection over 30 seconds).
Sponsors
Yan'an City Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years; 2. Body mass index (BMI) 18.5-34.9 kg/m^2; 3. American Society of Anesthesiologists (ASA) physical status classification I-III; 4. Scheduled for painless gastroenteroscopy.
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate in the study; 2. Patients with cognitive dysfunction or inability to communicate; 3. Contraindications for gastrointestinal endoscopy (e.g., gastrointestinal perforation, obstruction); 4. Severe difficult airway; 5. Uncontrolled hypertension (systolic blood pressure > 180 mmHg); 6. Contraindications for benzodiazepines or opioids; 7. Severe liver and kidney dysfunction; 8. History of opioid or other analgesic abuse; 9. Unforeseen events such as gastrointestinal bleeding or perforation; 10. Any other factors deemed unsuitable for participation in this clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intraoperative awareness;Postoperative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactLi Yi
Yan'an City Chinese Medicine Hospital
Outcome results
None listed