Upper limb motor dysfunction after stroke
Conditions
Interventions
Test group:Brain-computer interface interaction for feedback-based upper limb rehabilitation training
Control group:Traditional upper limb circular motion training
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. First onset, or previous onset without obvious sequelae; 2. Meets the diagnostic criteria for ischemic stroke or hemorrhagic stroke, with a disease course of 2 weeks to 6 months; 3. The patient's age is between 35 and 75 years old (including 35 and 75 years old), and gender is not limited; 4. Moderate to severe upper limb motor dysfunction caused by unilateral hemisphere stroke (FMA-UE <= 47 points); 5. Sitting balance is at level 1 or above; 6. Has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are neurological deficits caused by bilateral hemispheric or subcortical lesions, stroke, brain tumors, brain trauma, fractures and other diseases; upper limb movement limitations, impairments, joint swelling, contractures, severe pain or other hand disorders; 2. The modified Ashworth scores of the affected side's upper limb shoulder, elbow, wrist and fingers are all between 3 and 4; 3. Patients with severe systemic diseases such as heart, lung, liver and kidney diseases that cannot be controlled by conventional medication; 4. Patients with consciousness disorders, severe aphasia, dysarthria, cognitive impairment, deafness, etc., unable to communicate normally, understand or follow instructions, or unable to cooperate with treatment and assessment; 5. Patients with malignant hypertension (sudden and significant increase in blood pressure, with both systolic and diastolic pressures increasing, often persisting above 200/130 mmHg); 6. Patients with malignant tumors; or patients with a life expectancy of less than one year due to causes other than stroke; 7. Patients with severe depression, anxiety states, or diagnosed with other mental disorders; 8. Patients with severe sensory disorders, severe neglect; 9. Patients with implanted or carrying pacemakers that may interfere with BCI; 10. Patients who received botulinum toxin injection treatment for the affected side's upper limb within 3 months before enrollment, or who considered using botulinum toxin injection treatment at any time during the study; 11. Patients with a history of alcohol abuse or drug abuse; 12. Patients with abnormal findings from other examinations that the investigator judges to be unsuitable for participation in this trial; 13. Pregnant or planning to become pregnant women of childbearing age; 14. Patients currently participating in other clinical research trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Motor Assessment-Upper Extremity, FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wolf Motor Function Test;Exercise capacity;Motor evoked potentials;Activity of daily life;Quality of life;EEG;TMS-EG;fNIRS; | — |
Countries
China
Contacts
Public ContactLi Hui
Xuanwu Hospital, Capital Medical University
Outcome results
None listed