prostate cancer
Conditions
Interventions
Bupivacaine Liposomal Group (Group B):Under ultrasound guidance, bilateral quadratus lumborum plane block was performed, with 20 mL of liposomal bupivacaine (133 mg/10 mL) injected on each side (i.e.,
Ropivacaine group (group R):Bilateral quadratus lumborum plane block was performed under ultrasound guidance, and 20mL (i.e., 60mg) of 0.3% ropivacaine was injected on each side.
Sponsors
Lishui People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75; 2. BMI: 19-28 kg/m^2; 3. Elective robot-assisted radical prostate cancer surgery; 4. ASA: I-III.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Contraindications to deep nerve block, including but not limited to anesthetic drug allergy, coagulation disorders (INR > 1.5 and/or platelet count < 70 x 10^9/L), injection site infection; 3. Chronic opioid dependence or chronic pain for more than 3 months; 4. Patients with mental illness or those who cannot cooperate with completing the rating scale; 5. Combined with severe cardiac, pulmonary, hepatic or renal dysfunction, such as liver decompensation (Child B/C grade), etc.; 6. Nerve block is not possible due to anatomical difficulties in ultrasound scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid consumption at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in heart rate and acute mean arterial pressure before and after skin incision was recorded;Time to first independent activity (defined as the time from performing the intervention to being able to move independently, e.g.getting out of bed and walking around);Incidence of perioperative heart rate and blood pressure fluctuations above 20% of the baseline value;Block-related complications: local anesthetic poisoning, nerve damage, puncture site infection, etc;Intraoperative (anesthesia induction to extubation) anesthetic drug consumption;Opioid consumption in the anesthesia resuscitation room;Incidence of complications (nausea, vomiting, dizziness, itchy skin, and urinary retention);Patients' anesthesia satisfaction;The postoperative QoR-15 recovery quality scale scores of the two groups at 24, 48 and 72 hours after surgery;Length of hospital stay;Need for other rescue analgesia (volume and time interval of first rescue analgesia in the ward);NRS scores at rest and cough at different times after surgery (immediate awakening, 10mins, 20mins, 30mins, 60mins, 2h, 6h, 6h, 24h, 48h, 72h).; | — |
Countries
China
Contacts
Public ContactChen Qian
Lishui People's Hospital
Outcome results
None listed