Global developmental delay,Intellectual disability,Cerebral palsy,Disorders of consciousness
Conditions
Interventions
Case group: Patients with global developmental delay, intellectual disability, cerebral palsy, and disorders of consciousness.:Noneeutic intervention)
Control group: Age- and sex-matched healthy developing children:None
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Case Group: 1. Clinically diagnosed with one of the following conditions: a. Global Developmental Delay (GDD) meeting the DSM-5 diagnostic criteria; b. Intellectual Disability (ID) with an Intelligence Quotient (IQ) = 8 years with adequate cognitive function), written assent must also be obtained. Control Group: 1. Age- and sex-matched to the case group (+/- 1 year). 2. No personal or family history of neurological disorders. 3. Normal developmental milestones (for children) or normal cognitive function (for adolescents). 4. No contraindications to MRI examination. 5. Voluntary participation with signed informed consent (for children, signed by the parent or legally authorized guardian).
Exclusion criteria
Exclusion criteria: 1. Contraindications to MRI examination, including: a. Implanted cardiac pacemaker, cochlear implant, or intracranial metallic implant (titanium alloy excluded, provided magnetic compatibility is confirmed); b. Claustrophobia precluding cooperation; c. Severe scoliosis or other postural limitations preventing supine positioning. 2. Comorbid neurological conditions requiring prioritized intervention (e.g., structural brain malformation, active epilepsy requiring immediate treatment). 3. Severe cardiopulmonary insufficiency precluding supine positioning. 4. History of neurosurgery within the past 3 months that may affect brain structure or function. 5. Inability to complete the scan without sedation indication or with sedation contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total brain volume;Default mode network (DMN) functional connectivity strength;Fractional anisotropy (FA);N-acetylaspartate/Creatine (NAA/Cr) ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pearson correlation coefficient (r) between multimodal MRI parameters and clinical scale scores (Gesell DQ, GMFM, CRS-R);Classification accuracy, sensitivity, and specificity (case vs. control) derived from multimodal MRI-based machine learning model; | — |
Countries
China
Contacts
Public ContactDengna Zhu
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed