Post-stroke aphasia
Conditions
Interventions
Trial group:Conventional language rehabilitation training + true stimulation targeting the right cerebellum (cTBS mode, intramplexus frequency 50Hz, interplexus frequency 5Hz, intensity 80%, motor thr
Control group:Conventional language rehabilitation training + pseudo-stimulation targeting the right cerebellum (pseudo-stimulation pulses, parameters the same as those of the true stimulation group)
Observational group:None
Normal control group:None
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for BA Patients (1) Aged 18 to 80 years (inclusive), with an education level of primary school or above; (2) Native speaker of Standard Mandarin, right-handed, with no family history of left-handedness; (3) Disease duration between 14 and 60 days, with language impairment as the primary symptom at onset; (4) For the second part of the study, patients with contraindications to TMS are excluded; (5) First-ever stroke, confirmed by CT/MRI, with a single lesion located in the left cerebral hemisphere; (6) Diagnosed as BA according to the Western Aphasia Battery; cognitive function assessed using the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA), excluding patients with aphasia combined with severe non-linguistic cognitive impairment; (7) Able to cooperate in completing neuropsychological assessments and imaging examinations; (8) Signed informed consent form. 2. Inclusion Criteria for HC (Healthy Controls) (1) Education level of primary school or above; (2) No history of cerebrovascular disease, traumatic brain injury, epilepsy, dementia, or other neurological disorders; (3) Normal function of heart, lungs, liver, kidneys, and other organs; (4) No visual field defects or peripheral hearing impairments; (5) Normal language function assessed by the Western Aphasia Battery (Aphasia Quotient > 93.8) and normal cognitive function assessed by the Montreal Cognitive Assessment (MoCA) (total score = 26); (6) No contraindications for MRI examination; no abnormalities detected on MRI; (7) Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for BA patients: (1) Pre-existing language impairment before the current onset, or language impairment caused by other reasons: history of transient ischemic attack; stroke caused by conditions related to cognitive impairment, such as moyamoya disease or amyloid angiopathy; (2) History of psychiatric disorders such as schizophrenia; patients with contraindications to TMS are excluded in the second part of the study; (3) Severe cardiac, hepatic, or renal insufficiency; (4) Visual field defects or peripheral hearing impairment; (5) History of craniotomy or previous epileptic seizures; severe dysarthria; consciousness disorder with Glasgow Coma Scale score of 15 points; (6) Imaging findings of cerebral small vessel disease, such as white matter lesions, microbleeds, enlarged perivascular spaces, or brain atrophy; (7) Comorbid depressive state after the current onset (Hospital Version of the Stroke Aphasic Depression Questionnaire, 10th edition, score >6); (8) Recurrent stroke or new intracranial lesions (such as space-occupying lesions) during the study; (9) Signed informed consent form; (10) Unable to complete TMS treatment; (11) Obvious head movement during magnetic resonance scanning (>3 mm), affecting image quality; (12) Unable to complete follow-up; (13) The patient voluntarily requests withdrawal from the study. 2. Exclusion criteria for HC: (1) History of stroke, intracranial space-occupying lesions, or other diseases; (2) History of definite psychiatric disorders such as schizophrenia, or comorbid depressive state.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Word Fluency Test,WFT;West Aphasia Battery,WAB;Phoneme-level test;Vocabulary-level test;Grammar-level test (sentence production);Boston Diagnostic Aphasia Examination,BDAE;Resting state functional nuclear magnetic related indicators;Edinburgh Handedness Inventory;Chinese Aphasia Fluency Characteristics Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Instrumental Activities of Daily Living Scale, IADL;Stroke and Aphasia Quality of Life Scale, SAQOL-39g;Loewenstein Occupational Therapy Cognitive Assessment,LOTCA;Stroke Aphasic Depression Questionnaire Hospital Version,SADQ-H; | — |
Countries
China
Contacts
Public ContactZhang Yumei
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed