Circadian rhythm disorder and periodontal disease
Conditions
Interventions
Exposure group:None
Control group:None
Sponsors
Shanghai Jiao Tong University School of Medicine Shanghai Ninth People's Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion Criteria for the Exposure Group (Circadian Rhythm Disorder Group) 1. Voluntarily participate in the study and sign a written informed consent form. 2. Aged 20–50 years. 3. Retain >=20 natural teeth. 4. Continuously working under the same work schedule for >=2 years, with night work >=3 times/month, engaging in night shifts or rotating shifts covering the period from 22:00 to 06:00. 5. Clear manifestations of circadian rhythm disorder in the past 6 months, including at least one of the following: 1) Habitually falling asleep after 1:00 AM. 2) Irregular sleep patterns (difference in sleep time between workdays and rest days >2 hours). 6. Pittsburgh Sleep Quality Index (PSQI) score >5. 7. No severe systemic diseases. (2) Inclusion Criteria for the Control Group (Normal Circadian Rhythm Group) 1. Voluntarily participate in the study and sign a written informed consent form. 2. Aged 20–50 years. 3. Retain >=20 natural teeth. 4. Regular daily schedule (long-term fixed sleep time between 22:00 and 24:00). 5. No history of night work. 6. PSQI score <=5. 7. No severe systemic diseases.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with type 1 or type 2 diabetes, or fasting blood glucose >=7.0 mmol/L, or glycated hemoglobin (HbA1c) >=6.5%. 2. Pregnant or breastfeeding women. 3. Received any form of periodontal treatment (including supragingival scaling, subgingival curettage, or periodontal surgery) within 3 months prior to screening. 4. Used systemic antibiotics, non-steroidal anti-inflammatory drugs, immunosuppressants, or biologics within the past month. 5. Clinically diagnosed organic sleep disorders, including obstructive sleep apnea syndrome (OSAS), restless legs syndrome (RLS), narcolepsy, etc. 6. Currently taking medications known to affect melatonin or cortisol rhythms, including but not limited to beta-blockers, exogenous melatonin preparations, systemic glucocorticoids. 7. Having systemic diseases known to affect periodontal health, including rheumatoid arthritis, inflammatory bowel disease (Crohn's disease, ulcerative colitis), systemic lupus erythematosus, Sjögren's syndrome, osteoporosis, etc. 8. Suffering from severe systemic diseases, including heart failure (NYHA III-IV), liver dysfunction (ALT or AST >=1.5 times the upper limit of normal), kidney dysfunction (eGFR =3 time zones in the past 6 months. 11. Currently undergoing orthodontic treatment. 12. Significant abnormality in complete blood count: white blood cell count 15,000/µL; absolute neutrophil count 10,000/µL; platelet count 500,000/µL. 13. History of major surgery or trauma within the past 6 months. 14. Other conditions deemed by the investigator to possibly affect study results or subject safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical attachment loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Probing depth;Bleeding index;Tooth movement;Morningness-Eveningness Questionnaire;Pittsburgh Sleep Quality Index;Munich Chronotype Questionnaire for Shift Workers;Circadian rhythm gene expression in periodontal tissues; | — |
Countries
China
Contacts
Public ContactWang Yuhua
Shanghai Jiao Tong University School of Medicine Shanghai Ninth People's Hospital
Outcome results
None listed