Adolescent Major Depressive Disorder
Conditions
Interventions
Cross-sequential sham stimulation group:Sham stimulation intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 12 and 18 years, regardless of gender. 2. meet the diagnostic criteria for depressive disorder according to the International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10); 3. HAMD-17 total score >= 17 points; 4. Right-handed; 5. After fully understanding the safety profile of TMS, willing to actively cooperate with the treatment, and providing signed informed consent from both the participant and their family members.
Exclusion criteria
Exclusion criteria: 1. Received MECT treatment within 6 months prior to enrollment. 2. Have a history of serious physical illness, or depression caused by other psychoactive substances or non-addictive substances. 3. Have metal or electronic devices implanted in the body, such as intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, or stents, among other metal foreign bodies. 4. Have a risk of seizure onset, including a history of craniocerebral disease, head trauma, alcohol use disorder, abnormal electroencephalogram (EEG), MRI evidence of structural brain abnormalities, or a family history of epilepsy. 5. Acutely suicidal individuals. 6. Those with psychotic symptoms requiring combined use of antipsychotic medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 17-item Hamilton Depression Rating Scale (HAMD-17) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores on other psychological and clinical symptom-related scales;Neurophysiological indices derived from multimodal neuroimaging;Scores of the Adverse Event Record Form; | — |
Countries
China
Contacts
Public ContactXiaoli Liu
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed