Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Conditions
Interventions
Dexmedetomidine Intranasal Spray Group:Prior to surgery, 1 µg/kg of dexmedetomidine intranasal spray was administered via intranasal inhalation.
Saline Group:Prior to surgery, normal saline was administered via intranasal inhalation.
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.The patient is over 18 years of age; 2.Meets the diagnostic criteria for acute myocardial infarction (AMI); 3.Has surgical indications, no surgical contraindications, and is scheduled for surgery; 4.Voluntarily participates in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Severe hepatic or renal insufficiency (Child-Pugh Class C or eGFR < 30 ml/min/1.73m²); 2.known hypersensitivity to dexmedetomidine; 3.severe hypotension, sinus bradycardia, and inferior/wall right ventricular myocardial infarction; 4.severe cardiac conduction block or severe heart failure (NYHA Class IV); 5.history of hemorrhagic cerebrovascular accident within 3 months; 6.presence of malignant tumor or severe infection; 7.anatomical abnormalities of the nasal cavity that affect intranasal drug administration; 8.mental illness or cognitive impairment that prevents cooperation with the study. 9.those who have previously undergone vascular reconstruction surgery or coronary artery bypass grafting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyper-sensitive troponin T; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatine kinase isoenzyme (CK-MB);N-terminal pro-brain natriuretic peptide (NT-proBNP); | — |
Countries
China
Contacts
Public ContactDunyi Qi
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed