none
Conditions
Interventions
Blank Control Group:Not injecting nalbuphine during the perioperative period
Post-Bone Cement Placement Administration Group (Group N1):Conventional anesthesia induction, anesthesia maintenance, intravenous injection of 0.2mg/kg nalbuphine after placement of bone cement
Induction Administration Group (Group n0):Conventional anesthesia induction, intravenous injection of 0.2mg/kg nalbuphine during induction
Sponsors
Shandong Provincial Qianfoshan Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. All study participants voluntarily enrolled in the trial and provided written informed consent after being fully informed of the trial’s purpose and significance; 2. Participants underwent unilateral total knee arthroplasty under general anesthesia; 3. Elderly participants (age >= 65 years), regardless of gender; 4. Body mass index (BMI) ranging from 18 kg/m² to 30 kg/m²; 5. Normal organ function; 6. Absence of psychiatric disorders, normal consciousness, and ability to communicate effectively; 7. American Society of Anesthesiologists (ASA) physical status classification I–III; 8. No contraindications to the study medications.
Exclusion criteria
Exclusion criteria: 1. Participants with uncontrolled or untreated hypertension (resting systolic/diastolic blood pressure >180/100 mmHg); 2. Individuals with severe respiratory diseases; 3. Subjects with abnormal liver or renal function (ALT and/or AST >2.5 times the upper limit of normal, total bilirubin >1.5 times the upper limit of normal, serum creatinine >1.5 times the upper limit of normal); 4. Individuals with a history of drug abuse, substance use, or alcohol abuse, where alcohol abuse is defined as an average daily alcohol intake exceeding 2 units (1 unit = 360 mL of beer, 45 mL of 40% alcohol by volume spirits, or 150 mL of wine).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS Scores of Study Participants at 30 Minutes Postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Requirement for rescue analgesic medication within 24 hours postoperatively;Hemodynamic indicators;VAS score;within 24 hours postoperatively was also documented.; | — |
Countries
China
Contacts
Public ContactGuo Liang
Shandong Provincial Qianfoshan Hospital
Outcome results
None listed