None
Conditions
Interventions
Midazolam group:Patients in midazolam group received IV midazolam 0.04 mg/kg followed by 0.1 mg/kg/h infusion.
Remimazolam group:Patients in remimazolam group received IV remimazolam 0.2 mg/kg followed by 1 mg/kg/h infusion.
Sponsors
Plastic Surgery Hospital, Chinese Academy of Medical Science & Peking Union Medical
College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 60 years; 2. American Society of Anesthesiologists (ASA) physical status class I or II; 3. Patients scheduled to undergo plastic surgery under procedural sedation and analgesia; 4. Ethical, voluntary participation of patients, and signing of informed consent.
Exclusion criteria
Exclusion criteria: 1. ASA scores > II; 2. Obesity (Body mass index [BMI] >= 30); 3. Obstructive sleep apnea/hypopnea syndrome; 4. Bradycardia (HR < 50 beat/min); hypotension (Mean arterial pressure [MAP] < 60 mmHg); 5. Severe disease (heart, pulmonary, hepatic or renal); 6. Known allergy to study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of respiratory depression (RR < 10 breaths/min); | — |
Secondary
| Measure | Time frame |
|---|---|
| Induction time of anesthesia;Lowest respiratory rate;Incidence of oxygen supplementation by facial mask;Incidence of thrusting the jaw;Incidence of hypotension ;Incidence of bradycardia;Frequencies of body movements;Frequencies of additional rescue;Recovery time;Recall of intraoperative events;Pain scores;Satisfaction score of patients;Satisfaction score of surgeons; | — |
Countries
China
Contacts
Public ContactWeipeng Xia
Plastic Surgery Hospital, Chinese Academy of Medical Science & Peking Union Medical College
Outcome results
None listed