Atlantoaxial instability
Conditions
Interventions
Cage Group:Atlantoaxial Lateral Mass Cage
Autologous Bone Group:Autologous Bone Grafting
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of atlantoaxial dislocation (preoperative dynamic X-ray indicates an atlantodental interval >3 mm). 2. Patients present with symptoms and signs of spinal cord or nerve root compression, such as numbness and weakness in the limbs, unsteady gait, or a girdle sensation, which may be accompanied by symptoms of spinal cord compression like bladder and bowel dysfunction, and for whom conservative treatment has been ineffective or symptoms are progressively worsening. 3. Patients without symptoms of nerve compression but with a clear diagnosis of atlantoaxial dislocation and evident atlantoaxial instability, who are at risk of severe complications such as paralysis from minor trauma. 4. Scheduled to undergo posterior atlantoaxial distraction reduction surgery, and the subject (or their legal guardian) is capable of providing written informed consent. 5. The patient is aged between 18 and 70 years old, with no gender restrictions.
Exclusion criteria
Exclusion criteria: 1. Cervical spondylosis (including but not limited to radiculopathy, myelopathy, cervical spinal stenosis), neurovascular malformations related to the cervical spine, ossification of cervical ligaments, trauma, tumors, inflammatory diseases such as tuberculosis, etc. 2. Concurrent spinal diseases in other regions (e.g., thoracic or lumbar spine) that affect the patient's clinical symptoms; presence of motor neuron diseases such as amyotrophic lateral sclerosis or other neurological disorders. 3. Participation in any other clinical trial within the past 3 months. 4. Comorbid psychiatric disorders, or cognitive impairment in the patient (or their legal guardian) that prevents the provision of fully informed consent. 5. Poor general physical condition rendering the patient unable to tolerate surgery; or preoperative evaluation deeming the patient unsuitable for surgical intervention. 6. Patients with poor cardiopulmonary function or advanced tumors; 7. Women who are pregnant, breastfeeding, or planning to become pregnant in the near future.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Horizontal Reduction Rate;Atlantoaxial Fusion Rate;Vertical Reduction Loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Short-From-36 Health Survey, SF-36 ;Cervical JOA (C-JOA) Score Recovery Rate;Visual Analogue Scale (VAS) Score; | — |
Countries
China
Contacts
Public ContactFuzhi Ai
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed