Persistent Atrial Fibrillation
Conditions
Interventions
MIL+ group:Pulmonary vein isolation plus mitral isthmus ablation
MIL- group:Pulmonary vein isolation
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age ranged from 30 to 80 years; 2.Persistent AF: duration of AF =6 months and < 5 years; Two random electrocardiograms and one Holter showed atrial fibrillation within six months before enrollment. Preoperative heart rhythm was atrial fibrillation; 3.Willing to sign an informed consent form; 4.Able to complete the study as required by the protocol;
Exclusion criteria
Exclusion criteria: 1. Paroxysmal atrial fibrillation; 2. The duration of AF was = 5 years; 3. Reversible causes of atrial fibrillation such as untreated hyperthyroidism; 4. Previous intervention for atrial fibrillation (including surgical maze procedure, catheter ablation, left atrial appendage occlusion, etc.); 5. Severe organic heart disease (such as severe mitral stenosis or regurgitation, severe aortic stenosis or regurgitation, hypertrophic obstructive cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy, etc.); 6. Thrombus and tumor were present in the atrium; 7. Left atrium diameter > 55 mm; 8. Contraindications to the use of heparin or oral anticoagulation; 9. Creatinine clearance < 30 ml/min; 10. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| freedom from any documented atrial arrhythmia recurrence after a single procedure; | — |
Secondary
| Measure | Time frame |
|---|---|
| freedom from any documented atrial fibrillation recurrence after a single procedure;The incidence of complications during perioperative and follow-up;freedom from any documented atrial tachycardia recurrence after a single procedure; | — |
Countries
China
Contacts
Public ContactSongwen Chen
Shanghai General Hospital
Outcome results
None listed