None
Conditions
Interventions
Group R:First, slowly administer sufentanil 0.1 µg/kg intravenously. After 60 seconds, the R group is given remimazolam 0.2 mg/kg intravenously.
Group C:First, slowly administer sufentanil 0.1 µg/kg intravenously. After 60 seconds, the C group is given ciprofol 0.3 mg/kg intravenously.
Group P:First, slowly administer sufentanil 0.1 µg/kg intravenously. After 60 seconds, the P group is given propofol 1.5 mg/kg intravenously.
Sponsors
The Second Affiliated Hospital Of Zhengzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 60–80 years; 2.American Society of Anesthesiologists (ASA) physical status classification ?–?; 3.Body Mass Index (BMI) 18–28 kg/m²; 4.Those who clearly understand and voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to the drugs used in this study or similar medications; 2. Presence of contraindications to painless gastrointestinal endoscopy, including concurrent gastrointestinal diseases such as gastric retention and pyloric obstruction; 3. Concurrent obstructive pulmonary disease or acute upper respiratory tract infection; 4. Concurrent severe organ dysfunction (e.g., significant impairment of liver and kidney function); 5. Definite central nervous system diseases (e.g., history of brain tumor, cerebrovascular accident); 6. Long-term use of analgesics or sedatives; 7. Presence of mental illness or cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| psychomotor function; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of intraoperative supplemental doses;incidence of adverse events;muscle function;hemodynamics data ;orientation; | — |
Countries
China
Contacts
Public ContactLi Zhisong
The Second Affiliated Hospital Of Zhengzhou University
Outcome results
None listed