Acute ischemic stroke
Conditions
Interventions
Intravascular treatment group:None
Standard medical management:None
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients hospitalized at the participating centers between January 1, 2022, and June 30, 2025; 2. Aged 18 years or older; 3. Pre-stroke modified Rankin Scale score = 1.2; if Option A is not applicable (e.g., some centers lack advanced imaging equipment or analytical software), Option B is used: CT criteria: no hypodensity on non-contrast CT within >= 40% of the hypoperfusion region on perfusion CT; or MRI criteria: diffusion-FLAIR mismatch (no hyperintensity on FLAIR within >= 40% of the diffusion-weighted imaging (DWI) lesion area), with the time window extended to 24 hours); 7. Admission NIHSS score >= 4 or clearly disabling symptoms (e.g., aphasia, hemianopia, etc.).
Exclusion criteria
Exclusion criteria: 1. Concurrent large vessel occlusion; 2. Mild or rapidly improving neurological deficit (prior to any treatment); 3. Imaging suggests the occlusion may be due to other causes (e.g., arterial dissection, vasculitis, moyamoya disease); 4. Presence of other intracranial pathologies that may affect prognosis (e.g., large unruptured aneurysm, arteriovenous malformation, intracranial tumor); 5. History of severe neurological or psychiatric disease that may interfere with neurological assessment; 6. Multiple vessel occlusions (e.g., bilateral anterior circulation or combined anterior and posterior circulation occlusions); 7. Severe systemic disease with a life expectancy of <1 year (e.g., advanced cancer, end-stage liver or kidney failure); 8. Inability to complete follow-up as anticipated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRS score at 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional independence ratio (defined as mRS <= 2);European Five Dimensional Health Scale (EQ-5D-5L) score;Barthel Index score;Patient Health Questionnaire-4 (PHQ-4) Score; | — |
Countries
China
Contacts
Public ContactXu Yun
Nanjing Drum Tower Hospital
Outcome results
None listed