Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Experiment group:Fudostatin Oral Solution
Sponsors
Subei People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Age range: 40 - 80 years old. Gender: No restrictions; 2: Patients with stable chronic obstructive pulmonary disease who meet the diagnostic criteria specified in the "Guidelines for Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease" (and who had no acute exacerbation within the previous 4 weeks before screening); 3: The pulmonary function classification is at levels 1 to 3 of the GOLD system; 4: There is dysfunction of the small airways (during screening, FEF25-75% was less than 65% of the predicted value); 5: CAT score >= 10; 6: Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1: Those who are allergic to fudostatin or any of its components; 2: Merge other diseases that severely affect lung function (such as bronchiectasis, asthma, pulmonary fibrosis, active tuberculosis of the lungs, lung cancer, etc.); 3: Accompanied by severe dysfunction of the heart, liver and kidneys; 4: Pregnant women, lactating women or those planning to become pregnant; 5: Those who have participated in other drug clinical trials within the past three months; 6: The researcher determined that there were no circumstances that would disqualify an individual from participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FEF25-75%(Forced Expiratory Flow at 25–75% of Forced Vital Capacity);FEV1(Forced Expiratory Volume in 1 second);RV/TLC (Residual Volume / Total Lung Capacity);Modified Medical Research Council Dyspnea Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of acute exacerbations;Quality of life score; | — |
Countries
China
Contacts
Public ContactMin Lingfeng
Subei People's Hospital of Jiangsu province
Outcome results
None listed