Fibrotic interstitial lung disease
Conditions
Interventions
hypoxic group:None
non-hypoxic group:None
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged >=18 years, male or female, either outpatients or inpatients; 2. definite diagnosis of fibrotic interstitial lung disease (fILD) established by multidisciplinary discussion (MDD), including but not limited to idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD (CTD-ILD), fibrotic hypersensitivity pneumonitis (FHP), idiopathic nonspecific interstitial pneumonia (iNSIP), sarcoidosis, and occupational or environmental exposure-related ILD; 3. clinically stable with no acute exacerbation within the past 1 month; 4. able to communicate verbally or in writing, and willing to undergo regular follow-up; 5. voluntarily participating in this study, with written informed consent obtained and approved by the ethics committee of each participating center.
Exclusion criteria
Exclusion criteria: 1. presence of other severe pulmonary diseases (e.g., lung cancer, asthma, COPD) or cardiovascular diseases (e.g., left heart failure, malignant arrhythmias); 2. presence of conditions leading to hypoxia, such as severe anemia, carbon monoxide poisoning, or cyanotic congenital heart disease; 3. presence of active infection, malignancy, or an immunocompromised state; 4. receipt of lung transplantation or participation in other interventional clinical trials within the recent 6 months; 5. presence of neuropsychiatric disorders, such as cerebrovascular disease, Parkinson's disease, or depression; 6. refusal of participation by the patient or their family members.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in Forced Vital Capacity (FVC);change in Montreal Cognitive Assessment Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of acute exacerbation;Change in HRCT fibrosis score;KBILD score;Strength, Assistance with walking, Rising from a chair, Climbing stairs, and Falls questionnaire, SARC-F;Fatigue Assessment Scale score;Incidence of death;change in 6-Minute Walk Distance (6MWD);Hospital Anxiety and Depression Scale;KL-6;Differential brain regions and abnormal functional nodes on brain MRI; | — |
Countries
China
Contacts
Public ContactChen Juan
General Hospital of Ningxia Medical University
Outcome results
None listed