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Correlation Analysis Between Preoperative Brain Network Abnormalities and Postoperative Pain After Lower Limb Joint Surgery: A Prospective Case-Control Study

Correlation Analysis Between Preoperative Brain Network Abnormalities and Postoperative Pain After Lower Limb Joint Surgery: A Prospective Case-Control Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600125349
Enrollment
Unknown
Registered
2026-05-26
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

Case group & control group:None

Sponsors

Xuanwu Hospital, Capital medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 65 years; 2. No gender restriction; 3. Patients undergoing general anesthesia or neuraxial (spinal) anesthesia for orthopedic surgery of the lower extremity joints (hip, knee, ankle); 4. Signed informed consent.

Exclusion criteria

Exclusion criteria: Patients meeting at least one of the following criteria: 1. Illiteracy, or a preoperative MMSE score 35; 8. Taking opioid medications; 9. Non-Han ethnicity; 10. Not using an analgesic pump.

Design outcomes

Primary

MeasureTime frame
Functional connectivity(FC);

Secondary

MeasureTime frame
Confusion Assessment Method (CAM) scale evaluation score;Montreal Cognitive Assessment (MoCA) scale evaluation score;Mini-mental State Examination (MMSE) scale evaluation score;Auditory Verbal Learning Test (AVLT) evaluation score;Ability of Daily Living (ADL) scale evaluation score;Clinical Dementia Scales (CDR) evaluation score;Clock Drawing Test (CDT) evaluation score ;Shape Trials Test B (STT-B) and Trial Making Test B (TMT-B) evaluation score;Hamilton Depression Scale evaluation score;Hamilton Anxiety Score (HAMA) evaluation score;Hachinski Ischemia Scale evaluation score;Fluency Test evaluation score;Numeric Rating Scale;Pain Detect Questionnaire;Western Ontario and McMaster Universities Osteoarthritis Index;

Countries

China

Contacts

Public ContactLei Zhao

Xuanwu Hospital, Capital medical University

zhaoalei@sina.com+86 138 1103 5886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026