Stroke
Conditions
Interventions
Intervention group:Respiratory-gated Auricular Vagal Afferent Nerve Stimulation, RAVANS
Aham stimulation group:RAVANS sham stimulation
Aspiration group after brainstem stroke:None
Non-aspiration group after brainstem stroke:None
Healthy Control Group:None
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
25 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with brainstem stroke-induced aspiration: 1. Aged 25-80 years; 2. First-ever unilateral brainstem stroke, confirmed by cranial MRI or CT, with disease duration less than 1 year; 3. Impaired swallowing safety indicated by VFSS, with a PAS score > 5; 4. Ability to cooperate with relevant examinations, including fMRI and VFSS-synchronized respiratory-swallow coordination monitoring; 5. Ability to cooperate with follow-up visits; 6. Voluntary provision of written informed consent. Patients with brainstem stroke without aspiration: 1. Aged 25-80 years; 2. First-ever unilateral brainstem stroke, confirmed by cranial MRI or CT, with disease duration less than 1 year; 3. Intact or mildly impaired swallowing safety indicated by VFSS, with a PAS score <= 5; 4. Ability to cooperate with relevant examinations, including fMRI and VFSS-synchronized respiratory-swallow coordination monitoring; 5. Ability to cooperate with follow-up visits; 6. Voluntary provision of written informed consent. Healthy controls: 1. Aged 25-80 years; 2. Good general health status with independent living ability; 3. No swallowing dysfunction as screened by swallowing screening scales or the water swallow test; 4. Ability to follow instructions for examinations and voluntary provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of multiple neurological lesions involving the cerebral cortex or subcortex, brainstem, cranial nerves, etc.; 2. Use of prokinetic agents, H2 receptor antagonists, sedatives, analgesics, antidepressants, or anticholinergic drugs within one month prior to enrollment; history of laryngeal tumors or gastrointestinal motility disorders; presence of severe cardiopulmonary or renal complications; 3. Inability to undergo examinations due to implanted or retained metal objects, installation of electronic devices such as cardiac pacemakers, unstable medical conditions, etc.; 4. Severe claustrophobia or refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory-swallow coordination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Penetration-Aspiration Scale score; | — |
Countries
China
Contacts
Public ContactQiao Jia
Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed