Non-small cell lung cancer
Conditions
Interventions
Trial group:Received HilumDirect uVATS for radical resection of NSCLC
Control group:Received conventional uVATS for radical resection of NSCLC
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: Primary Inclusion Criteria: 1. Age between 18 and 79 years; 2. Patients with lung cancer requiring radical pulmonary resection; 3. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1; 4. Suspected pulmonary malignancy based on chest computed tomography (CT) or positron emission tomography-CT (PET-CT) scans; 5. Peripheral tumors, defined as tumors located at or distal to the opening of the segmental bronchus; 6. Primary pulmonary tumor without invasion or metastasis to other lung lobes; 7. Preoperative clinical stage T1-3N0-1M0 (according to the 9th edition of the AJCC/UICC TNM staging system), excluding the following types: (1) Cases with involvement of vital organs such as the diaphragm, superior vena cava, or spine; (2) cN1 cases with extranodal extension (CT scan indicating invasion of adjacent bronchi or pulmonary vessels); 8. No previous history of surgery for thoracic malignancies; 9. No prior neoadjuvant radiotherapy, neoadjuvant chemotherapy, or neoadjuvant chemoradiotherapy, and no prior administration of targeted therapy or immunotherapy drugs (a history of chemotherapy or hormonal therapy for malignancies in other parts of the body is permissible); 10. Predicted postoperative forced expiratory volume in 1 second (FEV1) >= 800 ml; 11. American Society of Anesthesiologists (ASA) physical status classification of I to III. Secondary Inclusion Criteria: 1. Surgery performed within 14 days after the initial assessment confirming eligibility based on the primary inclusion criteria; 2. Intraoperative confirmation of the feasibility of radical resection; 3. No intraoperative evidence of malignant pleural effusion or intrathoracic dissemination.
Exclusion criteria
Exclusion criteria: 1. Synchronous double or multiple tumors, or metachronous double or multiple metastatic tumors; 2. Pulmonary tumors requiring pneumonectomy for radical resection; 3. Presence of an active infection requiring systemic antimicrobial therapy; 4. Severe psychiatric disorders; 5. Currently receiving or having recently (within 2 weeks) received continuous corticosteroid or immunosuppressive therapy; 6. Hypertension or diabetes mellitus uncontrolled by systemic medical treatment; 7. A history of severe heart disease, heart failure, or myocardial infarction within the past 6 months, or confirmed episodes of angina pectoris within the past 6 months; 8. Interstitial lung disease, pulmonary fibrosis, or severe emphysema; 9. Postoperative pathological confirmation of lesions other than non-small cell lung cancer (NSCLC).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chronic pain; | — |
Countries
China
Contacts
Public ContactZHANG XINING
Peking University First Hospital
Outcome results
None listed