Total Knee Arthroplasty
Conditions
Interventions
Group A:ACB block: 10 ml normal saline under ultrasound guidance.
Periarticular injection: Liposomal bupivacaine 20 ml (266 mg) diluted to a total volume of 60 ml.
Group B:ACB block: Liposomal bupivacaine 66.5 mg diluted to 10 ml under ultrasound guidance.
Periarticular injection: Liposomal bupivacaine 199.5 mg diluted to 60 ml.
Group C:ACB block: Liposomal bupivacaine 133 mg/10 ml, total 10 ml.
Periarticular injection: Liposomal bupivacaine 10 ml (133 mg) diluted to 60 ml.
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Scheduled for unilateral, primary total knee arthroplasty (TKA); 3. ASA physical status class I–III; 4. Voluntarily participate and sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Change in surgical plan or failure of anesthesia (e.g.ACB block failure) 2. Allergy to study drugs (e.g., liposomal bupivacaine) 3. Long-term preoperative opioid use (>3 months) or ongoing pain management 4. Surgical site infection or internal fixation in the knee 5. Recent (within 14 days) use of corticosteroids 6. Severe liver disease, pregnancy, or lactation 7. BMI > 40 kg/m² 8. Any other condition that, in the investigator’s opinion, may increase risk or interfere with study assessments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and exercise VAS scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily pain scores (least/worst);Morphine milligram equivalents (MME) or morphine consumption;Functional recovery: Knee range of motion (ROM);KOOS score at 1 month postoperatively;NKSS score at 1 month postoperatively;OKS score at 1 month postoperatively;NSAID consumption;Time to first rescue analgesia request;Incidence of adverse events(Nausea, vomiting, pruritus, drowsiness, respiratory depression, hypotension);Long-term adverse events (wound complications, deep vein thrombosis); | — |
Countries
China
Contacts
Public ContactZhang Huafeng
Tianjin Medical University General Hospital
Outcome results
None listed