Pain
Conditions
Interventions
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Over 18 years old; 2.Gender not limited; 3.From April 2025 to April 2026, the patient received treatment at the Fifth Affiliated Hospital of Sun Yat-sen University; 4.Those who have undergone elective or emergency abdominal surgery; 5.Postoperative analgesia was administered using patient-controlled intravenous analgesia (PCIA), with oxycodone or tajiridin being the primary analgesic drugs; 6.Postoperative hospital stay >=48 hours;
Exclusion criteria
Exclusion criteria: 1.Patients with a history of chronic pain before surgery and long-term use of opioids (>=3 months or daily oral morphine equivalent dose >30mg); 2.Known allergy to oxycodone or tegafur; 3.Severe hepatic impairment (Child-Pugh C) or renal impairment (eGFR < 30 mL/min/1.73m²); 4.Patients with preoperative chronic respiratory failure (resting SpO2 < 90% or requiring home oxygen therapy) or uncontrolled obstructive sleep apnea (AHI = 30) were admitted to the hospital. 5.Uncontrolled mental illness (such as major depressive disorder, schizophrenia) or history of substance abuse; 6.Reoperation is required during or within 24 hours after surgery due to bleeding, anastomotic leakage, or other reasons. 7.Postoperatively transferred to the ICU and mechanically ventilated for more than 24 hours;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain scores at rest and during activity within 48 hours post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative nausea and vomiting; | — |
Countries
China
Contacts
Public ContactYing Wang
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed