Postoperative Gastrointestinal Dysfunction
Conditions
Interventions
Placebo Group:Normal saline nasal spray, administered as nasal spray to the nasal cavity 30 min before anesthesia induction and during preoperative visit (17:00-17:30), with slow inhalation of the dru
Dexmedetomidine Nasal Spray Group:100 ug dexmedetomidine hydrochloride nasal spray, administered as nasal spray to the nasal cavity 30 min before anesthesia induction and during preoperative visit (17
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 65 years old; 2.American Society of Anesthesiologists (ASA) physical status classification Grade I to III; 3.Patients scheduled for elective gynecological laparoscopy under general anesthesia; 4.Patients who agreed to participate in this study and signed the written informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients who are not suitable for nasal spray administration or unwilling to receive intranasal medication; 2.Patients with a history of opioid abuse, or hypersensitivity to dexmedetomidine hydrochloride or any other medications used in this study; 3.Patients with stress ulcer, intestinal obstruction, bacterial translocation, or abdominal compartment syndrome; 4.Patients with a history of previous abdominal surgery; 5.Patients with preoperative severe cardiovascular, cerebrovascular, hepatic or renal dysfunction; 6.Patients with hypotension, bradycardia or sinus arrest; 7.Patients with airway hyperresponsiveness, such as asthma and chronic obstructive pulmonary disease (COPD); 8.Patients unable to communicate normally, including those with hearing impairment, language comprehension disorder, mental illness and other related conditions;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative opioid dosage;Postoperative sleep quality;Incidence of intraoperative adverse reactions;Inflammatory indicators;Postoperative pain numerical rating scale (NRS) scores;Time to first postoperative defecation;Intake, Feeling nauseated, Emesis, Exam, and Duration of Symptoms Scoring System (I-FEED); | — |
Countries
China
Contacts
Public ContactZhao Linlin
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed