The Preventive Effect of Enzyme-Based Stone Dissolution Therapy on Calcium Oxalate Calculi

Clinical Observation on the Efficacy of Enzyme-Based Stone Dissolution Therapy in Preventing Postoperative Recurrence of Calcium Oxalate Calculi

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600125323

Enrollment

Unknown

Registered

2026-05-25

Start date

2026-05-25

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

calcium oxalate kidney stones

Interventions

Enzyme-Based Stone Dissolution Therapy group:Enzyme-Based Stone Dissolution Therapy

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Age range between 18 and 75 years old; 2. Patients with calcium oxalate stones undergoing surgical treatment in a hospital; 3. Postoperative CT confirming residual stones of 2-8 mm; 4. Stone recurrence = 2 times in the past 2 years; 5. Voluntarily signed informed consent; 6. Complete clinical data can be obtained.

Exclusion criteria

Exclusion criteria: 1. The composition of the stones is confirmed to be infectious stones; 2. Patients with renal insufficiency (eGFR < 60); 3. Patients with intestinal diseases affecting oxalate absorption; 4. Patients who are unwilling or unable to sign the informed consent form and refuse to participate in this study.

Design outcomes

Primary

Measure	Time frame
Residual stone clearance rate;	—

Countries

China

Contacts

Public ContactBiao Xie

Meizhou People's Hospital

1014493346@qq.com+86 753 213 6190

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026