Ureteral calculi
Conditions
Interventions
intranasal drops(Group D ) :At 20 minutes before anesthesia induction, dexmedetomidine 1 µg/kg was administered via intranasal drops, with the solution divided equally between both nostrils and instil
Spray group (Group P):At 20 minutes before anesthesia induction, dexmedetomidine 1 µg/kg was administered via intranasal spray. The spray nozzle was directed toward the lateral wall of the nasal cavit
Sponsors
Huai'an Fifth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–65 years; 2. Scheduled for elective transurethral holmium laser lithotripsy for ureteral calculi under general anesthesia with tracheal intubation; 3. American Society of Anesthesiologists (ASA) physical status classification I–III; 4. Body mass index (BMI) 18–28 kg/m²; 5. Patients and their families provided informed consent, voluntarily participated, and signed written informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Severe cardiac insufficiency, arrhythmia, poorly controlled hypertension, severe bradycardia (HR 3 times the upper limit of normal, Cr > 177 µmol/L); 5. Allergy or contraindication to dexmedetomidine, propofol, esketamine, lidocaine, rocuronium, or other study-related medications; 6. Anticipated difficult airway (Mallampati class III–IV); 7. Long-term preoperative use of sedatives, analgesics, or sympatholytic agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;Bispectral Index;Anesthesia induction time;Extubation time;Ramsay Sedation Score at 10 minutes after extubation;Total intraoperative propofol consumption; | — |
Countries
China
Contacts
Public ContactSun Xiaojing
Huai'an Fifth People's Hospital
Outcome results
None listed