Sepsis
Conditions
Interventions
Conventional two-step infusion group:Meropenem 2g, first 0.5g infused intravenously at a fixed rate over 30min, followed by 1.5g infused at a fixed rate over 2.5h
TCI target-controlled infusion group:Self-developed TCI pump infusion (blood drug concentration controlled based on PK/PD model)
Conventional continuous infusion via micro-pump group:Meropenem 2g infused via micro-pump at a fixed rate over 3h
Sponsors
Tangdu Hospital of the Fourth Military Medical University of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years old 2.Clearly identified patients with severe infections 3. Highly suspected bacterial infections 4.Have meropenem indications
Exclusion criteria
Exclusion criteria: 1. Make a clear diagnosis of non-bacterial infection. 2. Pregnant and lactating women. 3. Patients who are allergic to meropenem or similar drugs or have severe adverse reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median duration of clinical cure and improvement with meropenem (days from initiation to discontinuation of target antibiotic, until ICU discharge, death, or day 28 after randomization, whichever occurs first); | — |
Secondary
| Measure | Time frame |
|---|---|
| 14-day mortality rate;28-day mortality rate;Modified Acute Physiology and Chronic Health Evaluation II (APACHE II) score after treatment;Sequential Organ Failure Assessment (SOFA) score;Duration of mechanical ventilation;Duration of vasopressor use;Length of ICU stay;Hospitalization cost;Improved monitoring method for carbapenem blood drug concentration;Establishment of f%T > MIC calculation model for carbapenems;Optimization of individualized carbapenem dosing regimens in critically ill patients; | — |
Countries
China
Contacts
Public ContactYao Linong
Tangdu Hospital of the Fourth Military Medical University of the People's Liberation Army of China
Outcome results
None listed