Axial spondyloarthritis
Conditions
Interventions
Experimental group:Benzathine penicillin/ETN dose reduction combined treatment regimen
Control group:ETN decremental maintenance therapy alone
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with axial spondyloarthritis who have completed the BPEAS trial and are currently in clinical remission (ASDAS-CPR normal range; 4.Patients with concurrent streptococcal infection (with laboratory or histological evidence of concurrent streptococcal infection) and positive FISH test results (indicating the presence of streptococcal RNA);
Exclusion criteria
Exclusion criteria: 1.Subjects with nasopharyngitis, active tuberculosis, inflammatory bowel disease and other infections, other rheumatic and immune diseases, malignant tumors, and comorbidities involving other bone and joint diseases; 2.Severe abnormalities in liver and kidney function (liver enzymes >= 2 times the normal value; creatinine >= 2 times the normal value); 3.Women who are pregnant, planning to become pregnant, or breastfeeding; 4.Moderate to severe heart failure (New York Heart Association class 3-4); 5.Active gastrointestinal ulcer/bleeding;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ASAS40 remission rate of the patient after 48 weeks of medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ankylosing Spondylitis Quality of Life Scale (SQOL-AS);The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES);Improvement rate of the Spondyloarthritis Research Consortium of Canada (SPARCC) score;Bath Ankylosing Spondylitis Global Score (BAS-G);Overall patient evaluation;Streptococcus infection indicator;Improvement rate of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Structural Score (SPARCC-SSS);Anteroposterior pelvic radiograph;Short Form 36 Health Survey (Physical Functioning, Mental Health) (SF-36);Swollen Joint Count, Tender Joint Count;ASAS40 response rate;Ankylosing Spondylitis Disease Activity Score based on C-reactive protein (ASDAS-CRP);Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score;Work efficiency and activity impairment questionnaire for specific health issues;Bath Ankylosing Spondylitis measurement index (basmi) score;Bath Ankylosing Spondylitis Functional Index (BASFI) score;Asas20 response rate; | — |
Countries
China
Contacts
Public ContactJun Xiao
Southern Medical University Southern Hospital
Outcome results
None listed