Bronchial asthma
Conditions
Interventions
Biological Therapy Group:Biological treatment
Conventional Therapy Group:Conventional inhalation therapy
Sponsors
The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years old, regardless of gender. 2. Diagnosed with bronchial asthma by the Department of Respiratory Medicine in our hospital, meeting any of the following criteria: (1) Positive bronchodilation test; (2) Positive bronchial provocation test; (3) The average daily circadian variation rate of peak expiratory flow (PEF) > 10%; (4) For patients with suspected asthma, after 4 - week diagnostic anti - asthma treatment, the improvement rate of FEV1 is = 12% and the absolute value is = 200 ml. 3. Both newly - diagnosed asthma patients and previously - treated patients (for previously - treated patients, record their previous treatment regimens). Asthma patients treated with biological agents are those who still have poorly controlled asthma after treatment with medium - to - high - dose ICS/LABA. 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The disease is in the acute exacerbation phase. 2. Suffering from malignant tumors, autoimmune diseases, systemic infectious diseases, and major organ dysfunction. 3. Having pleural diseases or chest deformities. 4. Having contraindications for PFT (Pulmonary Function Test) and any EIT (Electrical Impedance Tomography) contraindications (such as pacemakers, implantable defibrillators, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Inhomogeneity Index;Centre of Ventilation Delay;Forced expiratory volume in one second, FEV1;Forced Vital Capacity, FVC;Ratio of FEV1 to FVC;Maximum Voluntary Ventilation,MVV; | — |
Countries
China
Contacts
Public ContactQu Shuoyao
The First Affiliated Hospital of Air Force Medical University
Outcome results
None listed