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The Role of E/I Balance and Frontal Alpha Asymmetry as Biomarkers in Depression: A Mechanistic Study

The Role of E/I Balance and Frontal Alpha Asymmetry as Biomarkers in Depression: A Mechanistic Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600125300
Enrollment
Unknown
Registered
2026-05-25
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Interventions

Sponsors

The first affiliated hostipal of nanchang university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 65 years; 2. No history of psychiatric disorders; 3. No severe somatic diseases; 4. No EEG contraindications; 5. Voluntary participation and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Brain organic diseases (e.g., stroke, tumor, epilepsy, Alzheimer's disease); 2. Severe somatic diseases (e.g., liver or kidney failure, arrhythmia, thyroid dysfunction); 3. History of substance abuse; 4. Pregnant or breastfeeding women; 5. History of brain trauma or intracranial surgery; 6. Inability to cooperate with EEG examination.

Design outcomes

Primary

MeasureTime frame
Frontal Alpha Asymmetry Index Based on Functional E/I Balance (fE/I-FAA);

Secondary

MeasureTime frame
Beck Depression Inventory-II (BDI-II) Score;Beck Anxiety Inventory (BAI) Score;Demographic Information;Clinical Subtype of Major Depressive Disorder;Previous Treatment History;EEG-Based Frontal Alpha Asymmetry (EEG-FAA) Index;

Countries

China

Contacts

Public ContactLi Mengqian

The first affiliated hostipal of nanchang university

limengqian@126.com+86 791 88692280

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026