Obstructive Sleep Apnea
Conditions
Interventions
Healthy Control Group:None
Post-operative OSA Patient Group:None
OSA Patient Group:None
Sponsors
The affiliated hospital of southwest medical university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years, voluntary participation with signed informed consent; 2. Ability to understand and communicate to complete study tasks, comprehend study instructions, and finish questionnaires and related assessments; 3. Agreement to undergo baseline PSG or validated HSAT, general physical measurements, and necessary biological sample collection, as well as consent to follow-up contact; 4. Meeting the ICSD-3 diagnostic criteria for OSA: AHI/RDI >=15 events/hour; or AHI >=5 events/hour with typical symptoms (e.g., snoring, witnessed apnea/awakening, daytime sleepiness or fatigue, etc.), with priority given to those with AHI >=15 events/hour; 5. No history of upper airway OSA-related surgery, or not in the post-operative recovery/follow-up period.
Exclusion criteria
Exclusion criteria: 1. Coexisting other sleep disorders, such as central sleep apnea, narcolepsy, severe restless legs syndrome, REM sleep behavior disorder, etc. 2. Subjects receiving CPAP therapy or having undergone upper airway surgery within the past 3 months. 3. Presence of severe somatic diseases that may significantly affect inflammatory or neurological indicators, such as uncontrolled diabetes, hyperthyroidism, active autoimmune diseases, chronic infections, or malignant tumors, etc. 4. Severe periodontal disease, or use of antibiotics, antimicrobial mouthwash, or other interventions that may affect oral microbiota within the past 1 month. 5. Subjects with other severe psychiatric/neurological disorders or significant cognitive impairment. 6. Subjects taking medications that may significantly affect the central nervous system or immune function and cannot discontinue use. 7. Pregnant or lactating women. 8. Subjects unable to complete key examinations such as PSG/HSAT, fNIRS, or with obvious poor adherence. 9. Subjects with alcohol abuse, drug abuse, or drug dependence. 10. Subjects deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea-Hypopnea Index (AHI);Neurocognitive Function Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Emotional Status Assessment; | — |
Countries
China
Contacts
Public ContactXiang Bo
The affiliated hospital of southwest medical university
Outcome results
None listed