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Clinical Study on the Effect of Different Exercise Modes Regulating BDNF on Cardiac Function and Exercise Tolerance in Patients with Stable Coronary Heart Disease

Clinical Study on the Effect of Different Exercise Modes Regulating BDNF on Cardiac Function and Exercise Tolerance in Patients with Stable Coronary Heart Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600125289
Enrollment
Unknown
Registered
2026-05-25
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stable coronary artery disease

Interventions

Conventional treatment group:Conventional drug therapy + rehabilitation nursing
aerobic exercise combined with resistance exercise group:aerobic exercise combined with resistance exercise

Sponsors

Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Diagnostic Criteria: (1) Meets the diagnostic criteria for SCAD as outlined in the "Guidelines for the Diagnosis and Treatment of Stable Coronary Heart Disease" (2018) issued by the Cardiovascular Disease Branch of the Chinese Medical Association and the Editorial Board of the "Chinese Journal of Cardiology", as well as the "Guidelines for Primary Care Diagnosis and Treatment of Stable Coronary Heart Disease" (2020), including chronic stable exertional angina, the stable phase following acute coronary syndrome, asymptomatic ischemic heart disease, spasm-induced angina, and microvascular angina. History of myocardial infarction; coronary angiography confirming coronary artery stenosis >= 50%; non-invasive testing confirming coronary artery stenosis or evidence of myocardial ischemia. (2) Meets the diagnostic criteria for XIONG BI in Traditional Chinese Medicine. Diagnosis is based on a holistic differential diagnosis through the integrated application of the Four Examinations (inspection, auscultation, inquiry, and palpation). Based on primary symptoms (stabbing pain in the chest and flanks, fixed and unmoving, triggered by emotional factors), secondary symptoms (flank distension, frequent sighing, and dark purple lips), and tongue and pulse findings (dark purple tongue or ecchymoses, and a string-like and rough pulse), the condition is diagnosed as Qi stagnation and blood stasis syndrome. 2. Inclusion Criteria: (1) Age 50-80 years. (2) New York Heart Association (NYHA) functional class I or II. (3) Alert and focused, able to cooperate fully with all assessments and exercise training. (4) Willing to undergo treatment and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with uncontrolled unstable angina pectoris and severe arrhythmias; 2. Patients with uncontrolled and unstable hypertension; 3. Patients with severe cardiopulmonary insufficiency; 4. Patients with severe hepatic or renal diseases, malignant tumors, or acute infections; 5. Patients with concomitant motor dysfunction; 6. Patients with impaired consciousness who are unable to follow instructions or complete assessments and motor tasks; 7. Patients with severe anxiety and depressive symptoms caused by illness who are unable to cooperate; 8. Patients who withdrew from the study midway due to various reasons.

Design outcomes

Primary

MeasureTime frame
cardiac function;brain-derived neurotrophic factor;cardio-pulmonary function;heart rate variability;

Countries

China

Contacts

Public ContactJianpeng Zou

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

910572449@qq.com+86 531 6890 1655

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026