Adolescents
Conditions
Interventions
Adolescent major depressive disorder group (MDD):None
Adolescent major depressive disorder with suicidal behavior group (MDDSA):None
Sponsors
The Second People's Hospital Of Taizhou
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. MDD Group (1) Meet the inclusion and exclusion criteria for clauses A, B, and C of Major Depressive Disorder (MDD) according to DSM-5; (2) Gender and age: No gender restriction, aged 12-18 years (stratified by male and female); (3) No severe heart, liver, or kidney diseases, no history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (4) No use of immunomodulators or hormonal preparations within at least the past 6 months, and no use of antipyretic analgesics within the past 2 weeks; (5) Signed informed consent form. 2. Major Depressive Disorder with Suicidal Behavior (MDDSA) Group (1) Meet the inclusion and exclusion criteria for clauses A, B, and C of Major Depressive Disorder (MDD) according to DSM-5; (2) Meet the inclusion and exclusion criteria for clauses A, B, C, D, and E of Suicidal Behavior Disorder according to DSM-5; (3) Clinical manifestations meeting clause A criteria within the past 3 days; (4) Presence of suicidal ideation; (5) Gender and age: No gender restriction, aged 12-18 years (stratified by male and female); (6) No severe heart, liver, or kidney diseases, no history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (7) No use of immunomodulators or hormonal preparations within at least the past 6 months, and no use of antipyretic analgesics within the past 2 weeks; (8) Signed informed consent form. 3. Healthy Control (HC) Group (1) Psychologically and physically healthy. (2) No history of self-harm, suicidal thoughts, or suicidal behaviors; (3) No history of psychiatric or psychological disorders; (4) Gender and age: No gender restriction, aged 12-18 years (stratified by male and female); (5) No severe heart, liver, or kidney diseases, no history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (6) No use of immunomodulators or hormonal preparations within at least the past 6 months, no use of antipyretic analgesics within the past 2 weeks, and no history of psychoactive substance abuse.
Exclusion criteria
Exclusion criteria: 1. MDD Group (1) Presence of severe heart, liver, or kidney diseases, or history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (2) Use of immunomodulators or hormonal preparations within the past 6 months, or use of antipyretic analgesics within the past 2 weeks; (3) Failure to sign the informed consent form. 2. Major Depressive Disorder with Suicidal Behavior (MDDSA) Group (1) Presence of severe heart, liver, or kidney diseases, or history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (2) Use of immunomodulators or hormonal preparations within the past 6 months, or use of antipyretic analgesics within the past 2 weeks; (3) Failure to sign the informed consent form. 3. Healthy Control (HC) Group (1) Presence of severe heart, liver, or kidney diseases, or history of tumors, hematological disorders, rheumatism, malnutrition, or neurodegenerative diseases; (2) Use of immunomodulators or hormonal preparations within the past 6 months, use of antipyretic analgesics within the past 2 weeks, or history of psychoactive substance abuse; (3) Failure to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Speech emotion recognition model (based on continuous affective description model with AI learning);False positive rate and false negative rate of adolescent MDD screening;EEG rhythm characteristics (including power spectrum, symmetry of alpha band distribution, and nonlinear dynamical parameters);Event-related potential (ERP);Exosomal miRNA expression levels;Beck Suicide Ideation Scale (BSI-CV);Ottawa Self-Harm Inventory (OSI-CV);Patient Health Questionnaire-9 (PHQ-9);Generalized Anxiety Disorder-7 (GAD-7);Adolescent Stressful Life Events Checklist (ASLEC);Demographic characteristics (age, sex, body weight, height, education level, economic status, family members' self-harm or suicide history, parental marital status); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical characteristics data (early trauma, diagnosis, treatment status, life events, depression, anxiety, self-harm and suicide behaviors, and suicide ideation); | — |
Countries
China
Contacts
Public ContactTang Yiping
The Second People's Hospital Of Taizhou
Outcome results
None listed