Extremely high-risk atherosclerotic cardiovascular disease
Conditions
Interventions
control group 1:Statin drugs for lipid-lowering treatment
control group 2:Statins combined with ivoosumab for lipid-lowering treatment
research group:Statins combined with racleciximab for lipid-lowering treatment
Sponsors
The Yunnan South Central Hospital (The First People’s Hospital of Honghe Prefecture)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. There have been 2 or more severe ASCVD events; 2. There has been 1 or more ASCVD events and at the same time, 2 or more high-risk factors are present; 3. Severe ASCVD events include: (1) Acute Coronary Syndrome (ACS) occurred within the previous 12 months; (2) History of myocardial infarction (more than 12 months); (3) History of ischemic stroke; (4) Symptomatic peripheral vascular disease, which has received blood flow reconstruction or amputation in the past. 4. High-risk factors include: (1) Multivessel disease (coronary artery, cerebral artery, and peripheral artery with 2-3 ischemic symptoms of arterial lesions simultaneously); (2) Early-onset coronary heart disease (male onset age 4.9 mmol/L; (4) Previously received coronary artery bypass grafting or PCI treatment; (5) Diabetes; (6) Hypertension; (7) Chronic kidney disease (CKD) stage 3-4; (8) Smoking; (9) After the maximum tolerated dose of statin treatment, LDL-C is monitored = 2.6 mmol/L.
Exclusion criteria
Exclusion criteria: 1. Severe liver dysfunction: Alanine aminotransferase (ALT) > 3 times the normal upper limit or having active liver disease; 2. Currently participating in other clinical trials; 3. Had a history of infection within the past two weeks; 4. Has contraindications or intolerance to the drugs used in this study; 5. Has a mental disorder and cannot cooperate with treatment; 6. Renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood glucose;total cholesterol;lipoprotein-associated phospholipase A2;Lipoprotein a;C-reactive protein;interleukin-6; | — |
Countries
China
Contacts
Public ContactTao Ma
The Yunnan South Central Hospital (The First People’s Hospital of Honghe Prefecture)
Outcome results
None listed