Cerebral vascular disease
Conditions
Interventions
Retrospective training cohort (retrospective poor prognosis group):None
Retrospective training cohort (retrospective good prognosis group):None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the retrospective cohort (1) Patients with carotid artery stenosis who underwent CAS surgery at Beijing Hospital and Beijing Tiantan Hospital in the past; (2) Stenosis location at the terminal segment of the common carotid artery and the C1 segment of the internal carotid artery, with a stenosis degree of more than 50%; (3) 18 years old =50% for symptomatic carotid artery stenosis patients and >=70% for asymptomatic carotid artery stenosis patients; (3) 18 years old <= patient age <= 80 years old; (4) Completed supra-aortic/head and neck CTA examination within 3 months before CAS surgery and retained the original phase information.
Exclusion criteria
Exclusion criteria: 1. Patients who underwent carotid artery occlusion surgery for acute occlusive disease of intracranial arteries; 2. Patients with severe stenosis in the intracranial arteries above the C2 segment of the internal carotid artery; 3. Patients with a history of neck radiotherapy or neck surgery, resulting in scar tissue hyperplasia around the internal carotid artery; 4. Patients without original phase information of supra-aortic/head and neck CTA; 5. Patients with a history of severe stroke, such as large-area cerebral infarction (preoperative mRS score greater than 3 points). Prospective cohort exclusion criteria: 1. Patients with non-atherosclerotic stroke mechanisms, including cardiogenic embolism (such as atrial fibrillation), carotid artery dissection, vasculitis, etc.; 2. Patients with malignant tumors and a history of systemic treatment; 3. Patients with severe underlying diseases that affect follow-up compliance, such as severe cognitive impairment, end-stage heart failure, etc.; 4. Patients with severe stenosis in the intracranial arteries above the C2 segment of the internal carotid artery; 5. Patients with incomplete general clinical baseline information and imaging data, or image quality not meeting the analysis requirements; 6. Patients with a history of neck radiotherapy or neck surgery; 7. Patients with a history of severe stroke, such as large-area cerebral infarction (preoperative mRS score greater than 3 points); 8. Patients with chronic atrial fibrillation, paroxysmal atrial fibrillation within the past 6 months or requiring anticoagulation therapy, myocardial infarction within 30 days, or unstable angina.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance metrics of carotid perivascular adipose tissue (PVAT) automated segmentation model (Dice coefficient, recall);Performance metrics of post-CAS ischemic risk prediction model (AUC, sensitivity, specificity); | — |
Secondary
| Measure | Time frame |
|---|---|
| Data quality and feasibility metrics (intraclass correlation coefficient, follow-up completion rate);Model generalizability metrics (external validation AUC, subgroup analysis performance); | — |
Countries
China
Contacts
Public ContactQi Peng
Beijing Hospital
Outcome results
None listed