Autism Spectrum Disorder
Conditions
Interventions
ASD Cohort:None
Control Cohort:None
Sponsors
Wenzhou Medical University School of Stomatology & Affiliated Stomatological Hospital
Eligibility
Sex/Gender
All
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: ASD group 1. Aged 2-17 years ASD group 2. Prior diagnosis of Autism Spectrum Disorder by a medical institution or professional assessment agency, with at least one of the following supporting documents: (a) ASD diagnostic report or medical record issued by a medical institution; (b) Disability certificate specifying autism; (c) Special education school enrollment certificate; (d) Rehabilitation institution registration certificate or assessment report. Patients whose parents clearly report a prior diagnosis but cannot provide any written documentation may still be enrolled, marked as verbal report only, and subjected to sensitivity analysis ASD group 3. Scheduled for elective dental treatment under general anesthesia at our hospital (including caries restoration, pulp therapy, extraction, and other routine dental procedures) ASD group 4. ASA physical status classification I-III ASD group 5. Written informed consent from legal guardian Control group 1. Aged 2-17 years Control group 2. No parent-reported diagnosis or clinical suspicion of ASD or other neurodevelopmental disorders (ADHD, intellectual disability, language developmental disorder, etc.) Control group 3. Scheduled for elective dental treatment under general anesthesia at our hospital Control group 4. ASA physical status classification I-II Control group 5. Written informed consent from legal guardian
Exclusion criteria
Exclusion criteria: 1. Severe congenital heart disease, uncontrolled epilepsy (=2 seizures within the past 3 months), or other serious systemic diseases that may affect the safety of general anesthesia 2. Severe hearing or visual impairment that would affect perioperative behavioral assessment 3. Known genetic metabolic diseases (phenylketonuria, mitochondrial disease, Rett syndrome, Fragile X syndrome, etc.) 4. Emergency surgery 5. Legal guardian unable to complete postoperative follow-up (no telephone or WeChat contact) 6. Legal guardian refuses to participate or withdraws informed consentS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of emergence delirium;Postoperative behavioral changes;Preoperative anxiety ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia induction compliance;Change in oral health-related quality of life;Postoperative changes in ASD core symptom domains;Changes in sleep patterns;Parental anxiety and caregiver burden;Longitudinal changes in social function and sensory processing; | — |
Countries
China
Contacts
Public ContactZhu Ge Jinru
School and Hospital of Stomatology, Wenzhou Medical University
Outcome results
None listed