None
Conditions
Interventions
Non-obese group :Sequential dose allocation was performed using the Dixon up-and-down method. All patients received an intravenous injection of 20 µg/kg oliceridine over 30 seconds, followed by intrav
obese group:Sequential dose allocation was performed using the Dixon up-and-down method. All patients received an intravenous injection of 20 µg/kg oliceridine over 30 seconds, followed by intravenous
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I–III; 2. Patients aged 18–75 years; 3. Body mass index (BMI) of 18–24.9 kg/m² and =30 kg/m²; 4. Scheduled to undergo painless gastrointestinal endoscopy.
Exclusion criteria
Exclusion criteria: 1. Inability to cooperate with intravenous induction; 2. Anticipated difficult airway; 3. Known or suspected allergy to study-related drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median effective dose (ED50) and 95% effective dose (ED95)**; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypoxemia;Respiratory depression;Apnea;Choking ;Hypotension;Bradycardia;Hemodynamics; | — |
Countries
China
Contacts
Public ContactGu Yinghua
General Hospital of Ningxia Medical University
Outcome results
None listed