Age-Related Hearing Loss
Conditions
Interventions
Community elderly group:None
Otolaryngology normal young group:None
Sponsors
The 6th Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Community elderly population: Inclusion criteria: (1) Age >= 60 years; (2) Conscious and able to cooperate with completing various assessments; (3)Commitment to cooperate with long-term follow-up for the local permanent resident population (residency >=9 months per year). 2.Normal young adults in the otology department: (1)Age 18-25 years (2)Pure-tone hearing thresholds at all frequencies (0.125 kHz - 8 kHz) <=10 dB. (3) Normal health status, without any symptoms of ear disease, no cerumen impaction in the ear canal, no history of excessive noise exposure, no history of ototoxic substance use, or familial hearing loss. 3. Longitudinal Follow-up Study In addition to meeting the aforementioned inclusion and exclusion criteria, patients enrolled in the longitudinal follow-up study must also satisfy the following criteria: (1) Sensorineural hearing loss; (2) Symmetrical bilateral hearing (i.e., the interaural threshold difference at each of the frequencies 0.5 kHz, 1 kHz, 2 kHz, and 4 kHz is <=15 dB); (3) Absence of hearing loss attributable to non-age-related factors.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Unable to cooperate with pure-tone audiometry 2. Neurological diseases: Parkinson's disease, stroke, intracranial tumor or trauma; 3. Major systemic diseases: combined with severe cardiac, pulmonary, hepatic, or renal insufficiency, or advanced malignant tumors, with an expected survival period of <3 years; 4. Any other situation deemed by the researcher to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pure-tone audiometry and degree of hearing loss;Rate of hearing decline;Cognitive function assessment results / risk of cognitive decline;Biomarkers associated with age-related hearing loss and cognitive impairment; | — |
Countries
China
Contacts
Public ContactYang Shiming
The 6th Medical Center of Chinese PLA General Hospital
Outcome results
None listed