Study on the Efficacy and Safety of Ciprofol for Sedation Therapy in Elderly Patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600125242

Enrollment

Unknown

Registered

2026-05-22

Start date

2026-05-31

Completion date

Unknown

Last updated

2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patient with mechanical ventilation

Interventions

ciprofol group:Using ciprofol for sedation

propofol group :Using propofol for sedation

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >= 65 years; 2. Patients admitted to the ICU who require invasive mechanical ventilation; 3. Expected sedation duration exceeds >= 24 hours; 4. The target Richmond Agitation-Sedation Scale (RASS) score for sedation of the patient is +1 to -2 points; 5. BMI is 18 - 30 kg/m^2; 6. The patient or their family member has signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Have contraindications or allergies to the studied drugs; 2. Have acute severe neurological diseases and any other conditions that interfere with the RASS assessment; 3. Cardiovascular system diseases: bradycardia requiring medication and/or heart rate = 50 beats per minute, II-III degree atrioventricular block (excluding patients using pacemakers), acute or chronic myocarditis; 4. Acute hepatitis or severe liver dysfunction (Child-Pugh C grade); 5. Chronic kidney disease patients with a glomerular filtration rate (GFR) of = 30 mL/(min * 1.73 m2); 6. Patients with high-level paraplegia and total paralysis; 7. Patients considered by the study to have uncontrolled hemodynamics; 8. Have a history of abuse of neuroactive drugs and anesthetic drugs; During the screening period, have a history of alcohol abuse within the previous 3 months, or have been taking long-term psychotropic drugs, etc.; 9. Pregnant or lactating; 10. Participating in other clinical trials of drugs; 11. Other situations where the investigator determines that the patient is not suitable for inclusion in the study.

Design outcomes

Primary

Measure	Time frame
The rate of achieving sedation without hypotension within 30 minutes;	—

Secondary

Measure	Time frame
Sedation Target Achievement Rate;Recovery Time;Duration of Invasive Mechanical Ventilation;Length of ICU Stay (ICU LOS);	—

Countries

China

Contacts

Public ContactDong Zhouzhou

Ningbo Medical Center Lihuili Hospital

lhlzhouyinchao@nbu.edu.cn+86 157 5746 7476

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026