Sepsis
Conditions
Interventions
healthy controls group:No
Sponsors
Tianjin Nankai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years, with no restrictions on gender or ethnicity; 2. Patients diagnosed with sepsis in accordance with the Sepsis 3.0 criteria; 3. Patients who provide informed consent to participate in this study and sign the informed consent form; 4. Healthy adult volunteers with age and gender matching as the control group.
Exclusion criteria
Exclusion criteria: A subject will be excluded from this study if he or she meets any of the following criteria: refusal to participate in the study; human immunodeficiency virus (HIV) infection; pregnancy or lactation; malignant tumor; organ transplantation; chronic viral infections (hepatitis, HIV); liver cirrhosis; chronic renal insufficiency; autoimmune diseases; use of immunosuppressive drugs within the previous 8 weeks; or current enrollment in another clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection and verification of blood proteomics;The association between biomarkers and patient outcomes and survival rates;Blood phosphoproteomics detection and validation;Blood peptidomics detection and validation;Determination and validation of blood metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood single-cell detection;Differential protease and kinase prediction;Prediction of protein phosphorylation modification sites;Validation of differential peptides; | — |
Countries
China
Contacts
Public ContactLirong Gong
Tianjin Nankai Hospital
Outcome results
None listed